There are special affinities between comics and architecture. The structure of a comic page follows architectural principles that significantly influence its reception. At the same time, urban architecture plays a crucial role in the stories of many comics, and the characters move through spaces that are meaningful and orienting, or have a labyrinthine character that, in the sense of deconstruction, decenters and thus disorients. The contributions collected in this volume examine the architecture of and in comics at the intersection of discursive and media practices. The basis for this is provided by theories of spatial concepts and configurations that have been considered in a wide variety of disciplines since the spatial turn: spaces are no longer understood as exclusively physical and territorial, but as relational, symbolically coded, and socially constructed concepts. Overall, this volume aims to explore an interdisciplinary field of comics research that has received little attention so far and to examine the media and symbolic significance of buildings and spaces, as well as the social practices associated with them.