This contribution offers a framework for the gambling phenomenon, highlighting the circular relationship between individual, territory, resources and lifestyles. The analysis from a medical and sociological dual perspective aims to provide new tools for reading the well-being/illness’ dynamics that can be delineated at a local level: in order to identify the high-risk contexts and behaviors; and to better intercept and interpret individual and collective requests and needs. The paper concludes by indicating some key advice and recommendations – applicable both at a policy level and at a social and healthcare operational level – with the aim of outline increasingly structured, long-lasting and interdisciplinary methods of prevention and treatment of gaming disorder, starting from the facilitating elements’ removal.